Clozapine Tablet (Clozadin^®)

What is Clozadin tablet used for? 

Clozadin is an antipsychotic drug indicated in the management of treatment-resistant schizophrenia and psychosis during the course of Parkinson’s disease.

How much and how often should Clozadin tablet be taken?

For treatment-resistant schizophrenia, start dose at 12.5 mg once or twice on the first day, followed by 25 mg once or twice on the second day. If well tolerated, the daily dose may be increased slowly in increments of 25 to 50 mg up to 300 mg/day within 2 to 3 weeks. In most patients, antipsychotic efficacy can be expected with 200 mg to 450 mg given in divided doses daily.

For psychosis during the course of Parkinson’s disease, starting dose must not exceed 12.5 mg/day taken in the evening. Subsequent dose increases must be by 12.5 mg increments up to a maximum of 50 mg given as a single dose in the evening. Maintenance dose for recurrence of psychotic symptoms may be given up to a maximum of 100 mg/day, taken in one or two divided doses.

What are the possible side effects of Clozadin tablet?

The most serious side effects are agranulocytosis, seizure, cardiovascular effects and fever. The most common side effects are drowsiness/sedation, dizziness, tachycardia, constipation and hypersalivation.

What is the available pack size of Clozadin tablet?

Clozadin is clozapine 25 mg tablet available in blister pack of 10’s in a box of 50’s and clozapine 100 mg tablet available in blister pack of 10’s in a box of 50’s.

FDA Registration number:

25 mg: DRP-11092-01

100 mg: DRP-11091-01